SilverCloud® by Amwell® Science Putting Evidence First

SilverCloud® by Amwell® Science Putting evidence first

At the forefront of evidence-base generation and digital health science.

Backed by nearly two decades of clinical research, Amwell®’s team of mental health experts deliver successful outcomes through the market’s most robust evidence-based behavioral change programs, empowering users to take control of their mental health and wellbeing.

Published research papers, citations, presentations at international academic conferences, and research projects continues to grow exponentially each year.

Our global research partners in digital health science

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Translating science into effective digital health solutions



Research PaperBridging the gap from medical to psychological safety assessment: consensus study in a digital mental health context


The aim of this study was to generate an experts’ consensus on how the medical regulatory method used for assessing safety could best be adapted for DMHIs.


Download Paper](https://silvercloud.amwell.com/resources/2024/research-paper/bridging-the-gap-from-medical-to-psychological-safety-assessment-consensus-study-in-a-digital-mental-health-context "Bridging the gap from medical to psychological safety assessment: consensus study in a digital mental health context")

Research PaperImplementing internet-delivered cognitive behavioral therapy in healthcare services


This study consisted of a qualitative exploration of stakeholder experience regarding the implementation of internet-delivered cognitive behavioral therapy (iCBT).


Download Paper](https://silvercloud.amwell.com/resources/2023/research-paper/implementing-internet-delivered-cognitive-behavioral-therapy-in-healthcare-services "Implementing internet-delivered cognitive behavioral therapy in healthcare services")

Research PaperPatient acceptance of self-monitoring on smartwatch in a routine digital therapy


In this study we investigated patient acceptance of the Mood Monitor smartwatch app within a routine 8-week iCBT program for depression.


Download Paper](https://silvercloud.amwell.com/resources/2023/research-paper/patient-acceptance-of-self-monitoring-on-smartwatch-in-a-routine-digital-therapy "Patient acceptance of self-monitoring on smartwatch in a routine digital therapy")

Research PaperThe effectiveness of low‑intensity psychological interventions for comorbid depression and anxiety


In this study we evaluated the effectiveness of low-intensity psychological interventions in the treatment of depression and anxiety in people with Long-Term Conditions (LTCs). \

Download Paper](https://silvercloud.amwell.com/resources/2023/research-paper/the-effectiveness-of-lowintensity-psychological-interventions-for-comorbid-depression-and-anxie "The effectiveness of low‑intensity psychological interventions for comorbid depression and anxiety")

Research PaperImplementing digital mental health interventions at scale: one-year evaluation of a national digital CBT service in Ireland


This study evaluated the first year of a supported digital cognitive behavioral therapy (CBT) service provided by the national health service in Ireland


Download Paper](https://silvercloud.amwell.com/resources/2023/research-paper/implementing-digital-mental-health-interventions-at-scale-one-year-evaluation-of-a-national-digital-cbt-service-in-ireland "Implementing digital mental health interventions at scale: one-year evaluation of a national digital CBT service in Ireland")

Research PaperTrajectories of symptoms in digital interventions for depression and anxiety using Routine Outcome Monitoring data


The aim was to identify latent trajectories of symptom change during the iCBT treatment course for depression and anxiety and to investigate the patients’ characteristics and platform usage for each of these classes.


Download Paper](https://silvercloud.amwell.com/resources/2023/research-paper/trajectories-of-symptoms-in-digital-interventions-for-depression-and-anxiety-using-routine-outcome-monitoring-data-a-secondary-analysis-study "Trajectories of symptoms in digital interventions for depression and anxiety using Routine Outcome Monitoring data")

Featured in top scientific journals

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Leaders in the science of digital health care

Collaborating with researchers at Harvard and West Virginia University to support a three-arm randomised control trial to evaluate the efficacy of adjunctive digital CBT for treating depression in rural communities in Appalachia in the Eastern United States. A key aim of this trial is to develop a stable individualized treatment rule that will allow patients and treatment providers to improve treatment outcomes by deciding collaboratively when standard primary care treatment should be augmented with digital CBT.

Appalachia Mind Health Initiative (AMHI)

Awarded a prestigious NIMH RO1 grant with our collaborators at Boston University and Kaiser Permanente. This grant will leverage machine learning to optimise user engagement and clinical response to digital mental health interventions, which will in turn inform optimal treatment allocation.

Leveraging machine learning for precision medicine